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The gene contains 4 exons. APOA1 encodes a 45.4 kDa protein that is composed of 396 amino acids; 21 peptides have been observed through mass spectrometry data. Apolipoprotein A-I (apo A-I) is a protein that has specific roles in the transportation and metabolism of lipids and is the main protein component in high-density lipoprotein (HDL, the "good cholesterol"). This test measures the amount of apo A-I in the blood. Lipids alone cannot dissolve in the blood; they are like oil that floats on water. APOA1 A gene on chromosome 11q23-q24 that encodes apolipoprotein A1, the main protein component of high-density lipoprotein (HDL) in plasma, which promotes cholesterol efflux from tissues to the liver for excretion and is a cofactor for lecithin cholesterolacyltransferase (LCAT), which is responsible for forming most plasma cholesteryl esters. Apolipoprotein A-I (apo A-I) is a protein that has specific roles in the transportation and metabolism of lipids and is the main protein component in high-density lipoprotein (HDL, the "good cholesterol").

Many studies revealing alterations of ApoA-I during the development and progression of various types of cancer suggest that serum ApoA-I levels may represent a useful biomarker contributing to 2021-01-01 · Rationale and design of ApoA-I Event Reducing in Ischemic Syndromes II (AEGIS-II): A phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to investigate the efficacy and safety of CSL112 in subjects after acute myocardial infarction 2013-01-03 · Dr. Remaley’s research has focused on the beneficial role of high-density lipoprotein (HDL), the so-called “good cholesterol.” HDL, which is a complex of the protein apoA-I with phospholipids, removes excess cholesterol from peripheral tissues, such as the arterial wall, and transports it to the liver and intestine for excretion from the (ApoA-I treated groups, 100 mg·kg−1 for ApoE−/− mice; 50 mg·kg−1 for Wrn mice), three times per week for 4 weeks. We evaluated effects on AVS using serial echocardiograms and valve histology. KEY RESULTS Aortic valve area (AVA) increased in both ApoE−/− and Wrn mice treated with the ApoA-I mimetic compared with placebo. Olympus apoa i Apoa I, supplied by Olympus, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more Apolipoprotein A‐I (apoA‐I), the principal apolipoprotein associated with high‐density lipoproteins in the periphery, is also found at high concentrations in the cerebrospinal fluid.

Disputation: Computational Protein Evolution: Modeling the

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av G Walldius · 2004 · Citerat av 359 — SwePub titelinformation: The apoB/apoA-I ratio is better than the cholesterol ratios to estimate the balance between plasma proatherogenic and antiatherogenic av V är Apo-kvoten — The apoB/apoA-I Ratio is a Strong Predictor of Cardiovascular Risk, Published in: Lipoproteins in Health and Diseases, ISBN 978-953-51-0773-6, eds. Frank S Specialistläkaren Karin Wallenfeldt visar i en ny avhandling att det kan vara säkrare att mäta kvoten mellan proteinerna apoB och apoA-I. Förutom att metoden Adenovirus-mediated gene transfer of apoA-IV in apoA-I(-/-) mice did not change plasma lipid levels. ApoA-IV floated in the HDL2/HDL3 region, promoted the Serum apolipoproteins, apoB/apoA-I ratio and objectively measured physical activity in elderly.

Explore apo GIFs. GIPHY Clips. I Apologize · Sorry Frog · Apologies · SORRY! Fancy Fountains, Sorry · I'm Trash · Sorry · I'm Sorry · Sorry! Miss Thang: Sorry. 28 Aug 2020 The most popular and well known mummies of world history were found in Egypt. But little did we know that there are also mummies with apoA-I amyloidosis: when a good protein turns bad.
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ApoA-I is inversely associated with insulin resistance in patients with impaired glucose tolerance, and low apoA-I is an independent risk factor for impaired glucose tolerance (IGT).

The ApoA-1 Milano mutation was found by University of Milan researchers after their 1974 investigation of a low HDL / high triglyceride phenotype exhibited by Valerio Dagnoli of Limone sul Garda, a small village in northern Italy.: 163 Limone had only 1,000 inhabitants at the time and when blood tests were run on the entire population of the village, the mutation was found to be 2003-01-01 apoA-I Antibody (2G4) is a mouse monoclonal IgG 1 provided at 100 µl; raised against apoA-I protein of human origin; recommended for detection of apoA-I of mouse, rat and human origin by WB, IP, IF and ELISA; See apoA-I (B-10): sc-376818 for apoA-I antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor ® 488, 594, 647, 680 and 790.
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Apolipoprotein A-I (ApoA-I), the major protein component of high-density lipoproteins (HDL) is a multifunctional protein, involved in cholesterol traffic and inflammatory and immune response regulation. Many studies revealing alterations of ApoA-I during the development and progression of various types of cancer suggest that serum ApoA-I levels may represent a useful biomarker contributing to ApoA-I/ApoB ratio to be the strongest modi ﬁ able protective factor (Yusuf et al. 2004).

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Oxidation of apoA-I by MPO has been reported to deprive HDL of its protective properties. However, the potential effects of MPO ApoA-I is a component of high-density lipoprotein (HDL). HDL is a molecule that transports cholesterol and certain fats called phospholipids through the bloodstream from the body's tissues to the liver. Once in the liver, cholesterol and phospholipids are redistributed to other tissues or removed from the body. ApoA-I, which is found exclusively in HDL, has a unique ability to capture and solubilize free cholesterol. This ApoA-I ability enables HDL to remove excess peripheral cholesterol, and return it to the liver for recycling and excretion.

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TY - JOUR. T1 - Structural properties of amyloidogenic apoA-I mutant L178H. AU - Axelsson, A. AU - Cochran, M. AU - Duong, T. AU - Chokshi, M. AU - Voss, J. C. Abstract.